Twin Bridge Capital Partners is a boutique private equity firm founded in 2005 that focuses exclusively on North American small and lower middle market buyouts, co-investments, and secondary investments. The firm has raised over $5.4 billion in capital since inception and manages multiple investment strategies including the Narrow Gate Series for small market buyouts, the Pacific Street Series for lower middle market buyouts, and the Amplify Series for single-asset continuation vehicles and c...

Launched by University of Illinois Board of Trustees 2002. Seed/early-stage VC for companies with U of I DNA. IT, physical sciences, life sciences, clean tech. Manages iVenture Accelerator with Origin Ventures.

Most active early-stage VC exclusively in Midwest. Chicago HQ. 14 states. Data-driven seed. 100+ companies.

Founded 1986 as UChicago initiative to commercialize UChicago + Argonne National Lab IP. Now independent deep tech + life sciences VC. Chicago + Seattle + SF offices. Deployed $3B+ in life sciences 2024–2025. Seed/early stage. Founding GP: Steven Lazarus; current MD: Keith Crandell.

Early-stage fund for underrepresented founders, especially Latinas. Founded by Samara Hernandez. Chicago IL. [merged from 1381]: Latina-led VC. Chicago.

Largest angel group in Midwest. Founded by Chicago Booth classmates. Enterprise, consumer, healthcare. Seed and early stage. "People First" model.

Chicago + Indianapolis B2B software VC. Seed–Series A. $250K–$4M checks. High-growth Midwest tech. SaaS, adtech, mobile. Notable: Geofeedia, Avant, FourKites.

Jump Capital is an early-stage venture capital firm that invests in founders building AI-driven solutions across industries. The firm provides capital, strategic guidance, and operational support to portfolio companies, with a team of partners and operating advisors who draw on experience in financial services and technology scaling.

Lakeshore Ventures — Alumni Ventures fund for the University of Chicago community. Co-invests alongside top VCs in University of Chicago-affiliated companies. Part of Alumni Ventures platform ($1.5B AUM, Manchester NH).

Founded by Groupon co-founders Eric Lefkofsky and Brad Keywell. Consumer tech, enterprise, fintech, climate. Seed through late stage. Notable: Groupon, Sprout Social.

$1.65B AUM over 4 funds. Growth-stage enterprise software and AI. HQ Santa Monica. Backed CrowdStrike, KnowBe4, Forter. Hosts The Montgomery Summit annually (~1,000+ attendees). Co-Founder & Managing Partner: Jamie Montgomery.

Chicago seed/early-stage VC.Teams with unfair customer acquisition advantage. Notable: Telnyx, NowSecure.

Chicago pre-seed/seed. Deep tech, hard tech, IoT, AI, blockchain, B2B SaaS for legacy industries. $42.6M Fund II.

Chicago early-stage tech, fintech, healthcare IT. Entrepreneur-friendly, hands-on. Connected to Northwestern ecosystem. $100M+.

Chicago multi-stage VC. E-commerce, digital media/adtech, B2B SaaS. Notable: Grubhub (seed), Braintree (early). Manages iVenture Accelerator at University of Illinois.

Venture arm of Pritzker family. Digital technology, consumer, manufactured products. Notable: Tempus AI (IPO June 2024, $6B valuation).

Purple Arch Ventures — Alumni Ventures fund for the Northwestern University community. Co-invests alongside top VCs in Northwestern University-affiliated companies. Part of Alumni Ventures platform ($1.5B AUM, Manchester NH).

Chicago food and agriculture venture fund. Transforms food system: supply chain, ingredients, distribution. Impact-driven.