BosonQ Psi (now operating as BQP) is a Syracuse, NY-based quantum computing software company whose platform leverages quantum approaches for system optimization, physics simulations, and large-scale AI/ML workloads on high-performance computers. Backed by Armory Square Ventures, BQP was named Upstate Capital's venture deal of the year for 2025.

Southern-Tier materials-science leader — optical fiber and Gorilla Glass (the cover glass on most smartphones).

Dimien was a Buffalo, NY-based battery and clean energy technology startup that originated in a University at Buffalo lab. The company developed advanced battery and chemical manufacturing solutions in the clean energy sector. In October 2024, Dimien was acquired by Pure Lithium, a Boston-based lithium metal battery firm, marking a milestone for the Western New York clean tech ecosystem.

The largest INDEPENDENT pure-play semiconductor foundry in the US — a merchant foundry that fabricates for others rather than for itself; HQ Malta NY (Capital Region). Specialty technologies, advanced packaging, and classical-quantum integration (cryogenic CMOS). The independence is the point: the open foundry the whole ecosystem can use, the overlooked-critical manufacturing layer rather than a c

Memory & storage semiconductor maker (HQ Boise ID). Building a $100B megafab complex in Clay NY near Syracuse for next-generation high-bandwidth memory — the upstate-NY semiconductor cluster, American chip manufacturing the coastal lens overlooks.

Albany NanoTech Complex — the public-private epicenter of US semiconductor R&D. Houses the CHIPS for America EUV Accelerator and serves as the bridge where IBM and partner firms prototype cutting-edge designs on 300mm wafers. Anchor of the NY Capital Region (Tech Valley) semiconductor cluster.

Phlotonics is a Rochester, NY-based biosensing company developing advanced photonic sensor platforms for real-time, label-free biomolecular detection to support biomanufacturing and drug discovery. In 2025, the company was awarded a $1.1 million AIM contract to advance its biosensor technology.

SunDensity is a Rochester, NY-based coating and materials company developing advanced photonic solutions to enhance sunlight capture and improve solar energy potential. Founded in Rochester, it operates within what it describes as the photonics capital of the world, leveraging local R&D infrastructure.