Wombat Security Technologies provided information security awareness and training software to help organizations teach employees secure behavior. A CMU spinoff based in Pittsburgh, PA, the company was acquired by Proofpoint in March 2018 for $225 million and rebranded as Proofpoint Security Awareness Training.

Safaba Translation Solutions was an enterprise machine translation software company providing automated translation solutions to global enterprises. The company was acquired by Amazon, after which its team became the Amazon Machine Translation R&D group. Following the acquisition, Safaba as a standalone product was discontinued.

Peachy Day is a migraine and headache care app that helps users track symptoms, understand headache patterns, and find relief through data-driven solutions. The app is designed as a one-minute daily ritual for iOS and Android, built by a team with over 125 combined years of experience.

4moms was a Pittsburgh-based baby products company known for innovative products including the mamaRoo infant swing. UPPAbaby acquired 4moms through an asset purchase agreement in July 2024, integrating the brand and its products under the UPPAbaby umbrella.

6K Additive manufactures premium metal powders and alloy additions for additive manufacturing via a microwave plasma process, at its Burgettstown, PA headquarters.

Accel Diagnostics is a medical diagnostics company developing proprietary point-of-care diagnostic assays for the diagnosis, monitoring, and management of various conditions. The company has proposed an innovative blood diagnostic test to aid the triage of patients presenting with head injuries, supported by SBIR funding.

Accipiter Systems, Inc. is a computer networking company specializing in optical and PCIe solutions for edge and fog computing. The company develops high-performance interconnect technologies designed to enable the next generation of real-time computing infrastructure.

ActivAided Orthotics designs and develops biofunctional gear and apparel that optimizes posture and body mechanics to eliminate back pain by training rehabilitative habits and behaviors. The company was acquired by ēlizur in August 2016.

Admirra is a CRM and workflow management platform purpose-built for mental health practices. The company helps mental health practice owners boost revenue and enhance access to care through comprehensive business solutions, and is a portfolio company of AlphaLab.

Adrich is a Pittsburgh-based IoT connected eCommerce technology company that delivers product usage and behavior insights along with sustainable replenishment solutions. The company offers patented product trackers that adhere to any type or size of packaging, combined with customized software.

AdSkate is an AI-powered creative intelligence platform that helps brands analyze and optimize advertising performance. Founded by industry veterans, AdSkate bridges creativity and data to help brands optimize ad performance 5x faster while increasing return on ad spend (ROAS) by up to 45%.

Advanced Optronics is a medical device company co-founded by engineers from Carnegie Mellon University developing flexible, biocompatible micro-scale sensor systems for real-time AI guidance in surgery. Founded in 2021 to commercialize CMU research, the company has received NSF grant support.

Aethon, Inc. is a provider of autonomous mobile robots for the healthcare and hospitality markets, automating routine delivery and transportation tasks to support clinical teams and staff. The company is a subsidiary of ST Engineering and serves hospitals with secure, autonomous delivery solutions.

Agentase LLC (an ICx Company) developed enzyme-based chemical agent detection technology, including kits and sprays designed to detect specific chemical warfare agents (CWAs) and other toxic industrial chemicals. Its Agentase C2 product line was later carried by FLIR Defense.

Agot AI is a computer vision platform company serving enterprise foodservice and fast-food operators, using AI to improve order accuracy and operational efficiency. The company raised a $10 million funding round in September 2021 to expand its technology in the restaurant industry.

AlgenAir is a company that develops living air purification technology using microalgae. Its flagship product, the aerium, is a natural indoor air purifier that uses Spirulina to produce oxygen and reduce carbon dioxide, providing the photosynthetic benefit equivalent to over 25 plants.

Allpoint Systems, LLC is a software and data processing company that offers solutions for collecting and processing LiDAR (laser) data. The company serves customers who work with geospatial and point-cloud datasets.

Allvision IO specializes in high-definition, time-based asset inventories for infrastructure, mobility, and transportation, using machine learning and automated data capture. The company provides continuously updated digital infrastructure maps for municipalities, public agencies, and private clients.

ALung Technologies, Inc. is a Pittsburgh-based medical device company that developed low-flow extracorporeal carbon dioxide removal (ECCO2R) technologies for treating patients with respiratory failure. The company originated from the University of Pittsburgh and was acquired by LivaNova PLC in July 2022.

Alveoli Corp, doing business as Lungs at Work, is a Canonsburg, PA nonprofit and the only freestanding Black Lung Clinic in the US, serving coal miners and families.