Jackson State University is a public historically Black university that offers undergraduate and graduate degree programs across five colleges: Business, Education and Human Development, Health Sciences, Liberal Arts, and Science, Engineering, and Technology. The university provides fully integrated learning that combines classroom instruction with laboratory work, community engagement, and research opportunities.

Coahoma Community College is a two-year institution founded in 1949 that offers Associate of Arts degrees, career and technical education programs, health sciences instruction, and workforce development services to students in Mississippi. The college provides academic courses for university-parallel concentrations, job preparation programs, and adult education across seven academic departments with a 16:1 student-faculty ratio.

Alcorn State University is a historically black land-grant institution located in Lorman, Mississippi that offers undergraduate and graduate academic programs through colleges of agriculture and applied sciences, arts and sciences, business, education and psychology, and nursing. The university serves thousands of students and is recognized for providing affordable higher education with a focus on developing both knowledge and character in its student body.

Belhaven University is a private Christian university headquartered in Jackson, Mississippi.

Delta State University is a public university headquartered in Cleveland, Mississippi, serving the Mississippi Delta region.

Millsaps College is a private liberal arts college headquartered in Jackson, Mississippi, founded in 1890.

Mississippi College is a private Baptist university headquartered in Clinton, Mississippi, home to the state's oldest law school.

Mississippi State University is a public research university offering over 100 undergraduate majors and 200 graduate programs across multiple locations including Starkville, Meridian, the Gulf Coast, and online. The university conducts research, provides outreach services, and hosts athletic programs while serving students, faculty, and staff.

Tougaloo College is a historically Black college founded in 1869 that offers associate degrees, undergraduate majors, and graduate degrees across schools including education, humanities, natural sciences, and social sciences. The college serves approximately 622 students and is located in Mississippi, with particular emphasis on preparing educators, healthcare professionals, and legal professionals for the state.

Public research university headquartered in Hattiesburg with a polymer science program tied to the Gulf Coast's shipbuilding and coatings industry.

William Carey University is a private university headquartered in Hattiesburg, Mississippi, with a Tradition, Mississippi Gulf Coast campus and colleges of osteopathic medicine and pharmacy.