$100B+ AUM. Co-founded by Marc Andreessen & Ben Horowitz 2009. Invests seed to growth across AI, bio, consumer, crypto, enterprise, fintech, games, infrastructure, American Dynamism. HQ Menlo Park CA. [2026-06-04, operator-stated: a16z has transitioned toward a PE/crossover model — invests in BOTH private and public companies (registered investment advisor; public-market positions held via the a16z Perennial sub-arm). Public holdings are core a16z activity, not a separate non-venture sidecar.]

SoCal's leading startup tech incubator (originally CommNexus 1998). Free incubation for early-stage startups. SD + Irvine + LA locations. No equity taken. Founded by Mike Krenn. Strong connections to local VC community. [merged from 823]: Southern California's leading startup technology incubator. San Diego flagship. Mentorship, capital access, strategic partnerships. Tech and deep tech focus. Key gateway to San Diego VC community.

Cross Culture + M Ventures merger. Seed.

Premier SD innovation accelerator (founded 1985). Merged with San Diego Venture Group 2019. Springboard program for tech and life sciences. CEO Mike Krenn (founder of Tech Coast Angels and EvoNexus). 400+ VC relationships. $800M+ raised for SD companies.

Data-driven co-investor. Uses AI/analytics to make rapid investment decisions (days vs months). Co-invests across all stages and sectors. Most active early-stage VC co-investor in US. Notable: Upstart, Mitek Systems. [merged from 820]: San Diego data-driven VC. Revolutionary model: rapid investment decisions using predictive analytics. Co-invests across multiple sectors and stages. Notable: Acuitas Medical ($85M Series D), Nerio Therapeutics (Avalon syndicate).

Exclusive life sciences VC since 1985. $2B AUM. Princeton NJ HQ + San Diego office. Pharma, medical devices, diagnostics. Has backed Neurocrine Biosciences across $100M+ in multiple rounds.

Leading agtech and life sciences VC. Global reach: US, Australia, Israel, New Zealand, Canada. Seed to late stage. San Diego + Palo Alto offices. Focus: food security, sustainability, ag innovation. [merged from 822]: San Diego agricultural technology and sustainability VC. Global reach with local roots. Early agtech pioneer. Invests in food security, precision agriculture, biotech for food systems.

DMV-active PE firm backing software and tech-enabled services. Active in DC government IT space.

$50M impact fund launched Feb 2025 by Prebys Foundation. Focus: tech and life sciences in San Diego region. Managing Director: Mike Krenn (former CONNECT CEO). Addresses critical capital gap in SD ecosystem.

LA startup studio and early-stage investor. Co-founder Peter Pham. Built Dollar Shave Club (sold to Unilever $1B), FabFitFun, PlayVS.

LA pre-seed specialist. Backs LA's most promising founders at earliest stages. Founder: Dustin Rosen.