Bacteriophage therapy for drug-resistant infections (PhageBank). I-270 corridor.

Adial Pharmaceuticals is a Charlottesville, Virginia-based clinical-stage biopharmaceutical company focused on developing treatments for alcohol use disorder and other addictions. Its lead therapeutic candidate targets the serotonin-3 receptor to reduce alcohol consumption. The company is publicly traded on the Nasdaq under the ticker ADIL.

CAR-T cell therapy (ddCAR / anito-cel for multiple myeloma). I-270 corridor.

Autoimmune therapeutics; lupus nephritis (voclosporin / LUPKYNIS). I-270 corridor.

mRNA cell therapy (Descartes platform) for autoimmune disease. I-270 corridor.

Cartesian Therapeutics, Inc. (NASDAQ: RNAC) is a clinical-stage biotechnology company pioneering mRNA cell therapies for the treatment of autoimmune diseases, headquartered in Frederick, Maryland. The company is advancing a pipeline of cell therapy candidates targeting serious autoimmune conditions. Cartesian is publicly traded on the Nasdaq exchange.

Emergent BioSolutions is a specialty biopharmaceutical company headquartered in Gaithersburg, Maryland, that develops, manufactures, and delivers medical countermeasures and specialty products protecting against public health threats for both civilian and military populations. The company has operated for more than two decades across intentional and naturally emerging health threats.

Value-based care platform for health plans and providers. Arlington VA. NYSE listed. NEA portfolio company.

NCI-sponsored national lab at Fort Detrick — cancer and biodefense research (the proving grounds).

AI-powered psychiatric care platform. Rockville MD. Founded by Dr. Bruce Alan Kehr (also founder of Potomac Psychiatry). Dr. Holo: AI agent for between-visit patient monitoring. Human-in-the-loop design. 90-day pilot with Banyan Treatment Centers: -36% actionable clinical escalations, 83% patient retention. Root Cause Psychiatry model. Backed by Jim Pearson and Joseph Mark.

Indoor Biotechnologies, now operating as InBio, is a Virginia-based company specializing in manufacturing biologics for allergy and asthma research. Recognized as a world leader in allergen assessment, the company conducts groundbreaking allergen research focused on advancing technologies and testing capabilities. It spun out of the University of Virginia.

Integrated BioTherapeutics, Inc. (IBT) is a biotechnology company focused on the discovery of novel vaccines and therapeutics for emerging infectious diseases. The company conducts research-based drug development targeting infectious disease threats. IBT also operates IBT Bioservices, a contract research organization offering preclinical and clinical research services.

Kura Oncology is a clinical-stage biopharmaceutical company committed to realizing the promise of precision medicines for the treatment of cancer. The company develops targeted therapies and is publicly traded, with offices in San Diego, California and Boston, Massachusetts.

MacroGenics is a clinical-stage biopharmaceutical company headquartered in Rockville, Maryland, focused on discovering and developing next-generation antibody-based therapies to improve the lives of cancer patients. The company leverages its proprietary antibody technology platforms to advance a pipeline of innovative oncology medicines.

Cell-engineering platform (Flow Electroporation) enabling cell & gene therapy. I-270 corridor.

Merand Pharmaceuticals is a drug discovery company headquartered in Charlottesville, VA that is developing a novel microRNA therapeutic to treat Peripheral Arterial Disease. The company is associated with the University of Virginia Licensing & Ventures Group.

MG Therapeutics is a University of Virginia spinout company (formerly MG Medicine) engaged in biopharmaceutical development. The company is listed among UVA Licensing and Ventures Group portfolio companies and was active as of 2024.

The US biomedical research agency — anchor of the Maryland life-science corridor (I-270 / Bethesda).

Brain-computer-interface medical device (wirelessly charged/connected deep-brain implant) for neurological disorders + cognitive enhancement; commercializing Dr. Newton Howard's IP. Former CEO Russ Hayward.

Novavax is a biotechnology company headquartered in Gaithersburg, Maryland, focused on developing and commercializing vaccine and adjuvant technologies to protect against infectious diseases. The company is known for its protein-based vaccine platform and its Matrix-M adjuvant, with R&D and manufacturing operations also based in Uppsala, Sweden.