Everactive is a deep technology company headquartered in Charlottesville, Virginia that creates groundbreaking wireless Ambient IoT devices powered by ultra-low-power circuit technology. The company's origins trace back to pioneering ultra-low-power circuit research conducted by its co-founders at the University of Virginia.

Laser Thermal (also known as Laser Thermal Analysis) is a Charlottesville, Virginia-based precision instrumentation company founded from academic research. It provides advanced thermal property measurement tools for semiconductors, power electronics, and thermal management applications. In 2023, the company announced a $2.9 million investment to expand R&D capacity in Charlottesville.

QC82 is a quantum computing company developing room-temperature, integrated photonic chips for fault-tolerant quantum computing. The company builds infrastructure for quantum computing using proprietary photon detection technology, targeting large-scale simulations in chemistry and materials science.