Centene Corporation is a leading managed care organization headquartered in St. Louis, Missouri, providing access to high-quality healthcare solutions for families and individuals. The company operates as a government-sponsored managed care plan across multiple states. Its corporate headquarters is located at 7700 Forsyth Boulevard, St. Louis, MO 63105.

Bold Stone Creamery is a St. Louis-based startup developing a line of adult-focused ice cream flavors targeted at sales in St. Louis stadium venues. The company was selected as part of Arch Grants' 2024 annual cohort, receiving between $75,000 and $100,000 in seed funding from the St. Louis nonprofit. As a condition of the grant, Bold Stone Creamery relocated to St. Louis to grow its business in the region.

St. Louis robotic magnetic navigation for cardiac procedures (NYSE: STXS).

AirSeal CardioVascular Inc. is a medical diagnostics company headquartered at 4340 Duncan Ave, St. Louis, MO, focused on transforming the detection and management of peripheral arterial disease (PAD). The company was founded in 2022 and is privately held.

Alfa-Ruby is a protein innovation company headquartered in St. Louis, MO that unlocks the full potential of alfalfa to produce high-performance plant protein. The company addresses the need for plant protein that does not compromise on taste, nutrition, or functionality compared to animal proteins. Founded in 2025, it is a privately held startup.

Allumin8 is a St. Louis-based medical device startup that develops FDA-cleared spinal fixation systems designed to reduce reoperation rates in spine surgery. The company's proprietary porous implant design allows surgeons to diagnose, treat, and accelerate healing directly through the implant. Allumin8 received FDA clearance in November 2025, becoming the first medical device company to achieve this milestone for its innovative hardware.

Archetype is a platform that transforms space planning and procurement for designers and developers, auto-generating on-spec layouts and curated product selections. The company is based in St. Louis, Missouri and is a recipient of an Arch Grants award.

ASL Aspire is an EdTech company based in St. Louis, MO that teaches STEM to K-12 deaf students and their teachers through American Sign Language. Its platform includes interactive arcade games, guided videos, practice modules, and quizzes to make learning STEM vocabulary in ASL engaging. The company has been recognized with a Global Impact Award from the Skandalaris Center at Washington University.

Astrapi is a St. Louis, MO-based communications technology company and world leader in nonstationary spectrum technology using spiral-based, non-periodic signal modulation. Its approach boosts spectral efficiency and provides robust signal protection for radio systems. Astrapi positions its spiral modulation as a game-changing advancement in wireless communications.

Balto is a St. Louis, MO-based contact center AI software company, founded in 2017, offering real-time agent guidance, automated quality assurance, business insights, coaching, and call summarization. Its platform is designed to help contact center agents perform better during live calls and improve overall team performance.

BenefitsBoost is a St. Louis, MO-based company that is revolutionizing the Social Security disability benefits process by making disability benefits applications faster and more accessible. The company serves disability advocacy groups and individuals, providing tools to streamline the benefits application experience.

Boat Planet is a St. Louis, MO-based web platform founded in 2018 where boat owners can find, compare, and book trusted and reviewed marine service professionals. The company is headquartered at 4220 Duncan Avenue, Suite 201 in Saint Louis and operates as a small privately held firm connecting boat owners with vetted marine pros.

Dad's Cookie Co. is a St. Louis, Missouri bakery that has been baking its original Scotch Oatmeal cookies since 1927. Cookies are baked daily and shipped free across the U.S. In 2024, a trio of brothers acquired the company, continuing its long-running south St. Louis tradition.

Geneoscopy is a St. Louis, Missouri life sciences company developing non-invasive RNA-based diagnostic tests to help prevent, detect, and monitor gastrointestinal diseases including colorectal cancer.

MediBeacon is a St. Louis, Missouri-based medical technology company focused on advancing fluorescent tracer agents and their transdermal detection to help improve patient care, particularly in kidney function monitoring.

nCase Technologies is a St. Louis, MO-based company that designs discreet, durable, and convenient carrying cases for lifesaving emergency medicines, with a focus on Naloxone (Narcan) carry cases. Headquartered at 4555 Forest Park Ave. in St. Louis, the company's mission is to remove practical barriers to carrying opioid overdose reversal medication. nCase Tech is a portfolio company of Arch Grants.

Posie Pots is a St. Louis, MO-based company founded by entrepreneur Kay Wells that makes self-watering planters crafted from eco-friendly 3D-printed materials, designed to fit busy lifestyles. The planters feature a built-in water reservoir and are sold directly to consumers.

Wugen is a clinical-stage biotechnology company based in St. Louis, Missouri, focused on developing cellular therapies. The company conducts research at its facility at 4260 Forest Park Avenue in St. Louis.

Zaiko is a St. Louis-based AI-driven software company focused on transforming inventory management and accounts payable for small, owner-operated grocery, convenience, and liquor stores. The platform helps independent retailers save time by eliminating manual inventory and AP processes. Zaiko was named a St. Louis Startup to Watch in 2025 by the St. Louis Business Journal.