AirSeal CardioVascular Inc. is a medical diagnostics company headquartered at 4340 Duncan Ave, St. Louis, MO, focused on transforming the detection and management of peripheral arterial disease (PAD). The company was founded in 2022 and is privately held.

Allumin8 is a St. Louis-based medical device startup that develops FDA-cleared spinal fixation systems designed to reduce reoperation rates in spine surgery. The company's proprietary porous implant design allows surgeons to diagnose, treat, and accelerate healing directly through the implant. Allumin8 received FDA clearance in November 2025, becoming the first medical device company to achieve this milestone for its innovative hardware.

Geneoscopy is a St. Louis, Missouri life sciences company developing non-invasive RNA-based diagnostic tests to help prevent, detect, and monitor gastrointestinal diseases including colorectal cancer.

MediBeacon is a St. Louis, Missouri-based medical technology company focused on advancing fluorescent tracer agents and their transdermal detection to help improve patient care, particularly in kidney function monitoring.

SentiAR is a St. Louis, Missouri-based digital health company developing holographic augmented reality technology for use during interventional medical procedures. Its AR platform provides physicians with a single real-time source of truth for intraoperative visualization.

St. Louis robotic magnetic navigation for cardiac procedures (NYSE: STXS).

Wugen is a clinical-stage biotechnology company based in St. Louis, Missouri, focused on developing cellular therapies. The company conducts research at its facility at 4260 Forest Park Avenue in St. Louis.