Alfa-Ruby is a protein innovation company headquartered in St. Louis, MO that unlocks the full potential of alfalfa to produce high-performance plant protein. The company addresses the need for plant protein that does not compromise on taste, nutrition, or functionality compared to animal proteins. Founded in 2025, it is a privately held startup.

Archetype is a platform that transforms space planning and procurement for designers and developers, auto-generating on-spec layouts and curated product selections. The company is based in St. Louis, Missouri and is a recipient of an Arch Grants award.

Balto is a St. Louis, MO-based contact center AI software company, founded in 2017, offering real-time agent guidance, automated quality assurance, business insights, coaching, and call summarization. Its platform is designed to help contact center agents perform better during live calls and improve overall team performance.

BenefitsBoost is a St. Louis, MO-based company that is revolutionizing the Social Security disability benefits process by making disability benefits applications faster and more accessible. The company serves disability advocacy groups and individuals, providing tools to streamline the benefits application experience.

Boat Planet is a St. Louis, MO-based web platform founded in 2018 where boat owners can find, compare, and book trusted and reviewed marine service professionals. The company is headquartered at 4220 Duncan Avenue, Suite 201 in Saint Louis and operates as a small privately held firm connecting boat owners with vetted marine pros.

Bold Stone Creamery is a St. Louis-based startup developing a line of adult-focused ice cream flavors targeted at sales in St. Louis stadium venues. The company was selected as part of Arch Grants' 2024 annual cohort, receiving between $75,000 and $100,000 in seed funding from the St. Louis nonprofit. As a condition of the grant, Bold Stone Creamery relocated to St. Louis to grow its business in the region.

Kultevat Inc. is a St. Louis, Missouri biotechnology company that combines plant breeding and green process engineering to produce specialty natural rubber from Kazakh Dandelion (Taraxacum kok-saghyz). The company is located at the Helix Center in the 39 North innovation district.