Augment Therapy is an award-winning digital health company headquartered in Cleveland, Ohio that creates augmented reality rehabilitation exercises and gamified wellness experiences for people of all ages and ability levels. The company raised $2.7 million in funding and was selected as a 2022 Unity for Humanity award recipient.

Axuall is a workforce intelligence company built on a national, real-time practitioner data network, serving the healthcare industry. Headquartered at 707 Huron Rd E in Cleveland, Ohio, the company partners with leading health systems, including Cleveland Clinic, to advance provider data integrity.

Centerline Biomedical is a Cleveland, Ohio medical device company and spinoff of Cleveland Clinic that develops FDA-cleared surgical navigation technology to reduce radiation exposure and improve accuracy in endovascular procedures. Its flagship Intra-Operative platform provides real-time navigation guidance for vascular surgeons.

Cleveland Diagnostics is a Cleveland, Ohio-based cancer biotechnology company focused on improving cancer detection decisions. It offers the IsoPSA test, a novel and more accurate diagnostic for early detection of cancer and risk of high-grade disease.

GenomOncology is a Cleveland, Ohio-based precision oncology software company that provides the healthcare community with data-driven insights and software solutions to improve cancer care. Its platform supports genomic data analysis and clinical decision-making for oncology teams.

Lazurite is a medical device company headquartered in Cleveland, OH (formerly known as Indago) that developed the ArthroFree wireless camera system for arthroscopy. The company has raised more than $18 million in private capital and is backed in part by University Hospitals Ventures.

MediView XR is a Cleveland, Ohio-based med-tech company pioneering the use of augmented reality (AR), mixed reality, and spatial computing to transform medical imaging and surgical guidance. The company collaborates with leading technology partners, academic institutions, and hospitals including the Cleveland Clinic to drive innovation in medical AR. MediView leverages remote connectivity and spatial computing data to advance digital health.

Neuros Medical is a privately held medical device company and maker of the Altius® Direct Electrical Nerve Stimulation System, an FDA-approved device designed to treat chronic post-amputation pain. The company is headquartered in Willoughby Hills, Ohio.

orthobrain is a Cleveland, Ohio-based dental practice growth system that empowers general dentists to integrate and deliver orthodontic services with confidence. It provides a combination of support, technology, and treatment systems designed to make orthodontics easy and profitable for general dental practices.

SPR Therapeutics is a privately held medical device company headquartered in Cleveland, Ohio, providing patients with a non-opioid, minimally invasive pain treatment option. The company employs nearly 100 people locally and more than 300 nationwide.

TPA Stream is a Cleveland, Ohio-based software company founded in 2014 that helps benefits and medical third-party administrators (TPAs) automate claims collection and produce cleaner employer invoices. Its platform turns disconnected billing and administrative data into streamlined operations for TPA teams, brokers, and employers.

Zuga Medical is a Chagrin Falls, Ohio-based medical device company and global leader in digital dentistry technology, manufacturing dental implant systems known for high quality and ease of use. Founded in 2007, the company is FDA-registered and operates facilities in the Cleveland, Ohio area.